Iodine levels are associated with oxidative stress and antioxidant status in pregnant women with hypertensive disease

نویسندگان

  • Sergio Cuellar-Rufino
  • Mónica Navarro-Meza
  • Pablo García-Solís
  • Irene Xochihua-Rosas
  • Omar Arroyo-Helguera
چکیده

BACKGROUND The antioxidant function of iodine and iodine deficiency as a risk factor of preeclampsia have been previously reported. AIM To analyze the association between iodine deficiency, oxidative stress and antioxidant status with hypertensive disease of pregnancy (HPD). METHOD Fifty-seven pregnant women were recruited in the last trimester of pregnancy; 20 were diagnosed with hypertensive disease (HPD) of pregnancy and 37 were normotensive pregnant women. Urinary iodine concentration (UIC), TSH, free T4 (fT4), total antioxidant status (FRP), superoxide dismutase (SOD), catalase (CAT), and oxidative stress (TBARS) were evaluated by colorimetric methods. RESULTS UIC median for all pregnant women was 151.9 µg/l. The UIC for pregnant women with HPD was 50-149 µg/l, compared to 150-249 µg/l in normotensive women. No significant differences in levels of TSH and fT4 in normotensive pregnant compared with HPD women were found. Pregnant women with HPD had significant high levels of TBARS, and significant low levels of FRP, SOD, CAT and UIC compared to normotensive pregnant. In addition, pregnant women with optimal levels of UIC had a higher SOD activity (r = 0.354, p = 0.011), while iodine deficiency was associated with HPD (r = -0,281, p = 0.039). Similarly, pregnant women with HPD had a significant negative association with SOD activity (r = -0.702, p = 0.005), CAT (r = -0.409, p = 0.002), and FRP (r = -0.624, p = 0.003), and a positive association with TBARS (r = 0.744, p = 0.001). CONCLUSION Iodine contributes to redox balance during pregnancy; its deficiency is associated with HPD. This study shows the importance of iodine during pregnancy.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Evaluation of Oxidative Stress and Antioxidant Status in Diabetic and Hypertensive Women during Labor

Pregnancy in insulin-dependent diabetes mellitus is associated with a greater incidence of fetal abnormality. Animal studies suggested that increased free-radical production and antioxidant depletion may contribute to this risk. The objective of this work was to evaluate oxidative stress and antioxidant capacity in hypertensive, diabetics, and healthy control women during labor. Simultaneous de...

متن کامل

Association between Glutathione peroxidase1 gene (GPX1pro198Leu) polymorphism with preeclampsia in south of Iran

Introduction: Preeclampsia is a common and serious hypertensive disorder affecting approximately 5-8 % of pregnancies. The biology of the disease is complex and not understood. This disease associated with increased blood pressure more than 140/90 mmHg in the second half of pregnancy and proteinuria more than 300 mg/24 h and is considered as one of the three leading causes of maternal and fetal...

متن کامل

Three cycles of AC chemotherapy regimen increased oxidative stress in breast cancer patients: A clinical hint

Background: Recent studies have suggested the importance of oxidant/antioxidant status in initiation and progression of breast cancer. The aim of this study was to evaluate oxidative stress markers in breast cancer patients before and after 3 cycles of chemotherapy with adriamycin and cytoxan (AC). Also, in this study the effect of age and the stage of disease on oxidative stress markers were c...

متن کامل

Effects of L-citrulline on Oxidative Stress Markers Following High Intensity Interval Exercises in Hypertensive Patients

Background and Objectives: High blood pressure affects nearly 30% of adults. Inactivity and low intake of antioxidants are associated with increased risks of high blood pressure and cardiovascular diseases. High intensity interval exercise increases blood pressure and oxidative stress. The purpose of this study was to investigate effects of L-citrulline consumption on oxidative stress and antio...

متن کامل

Oxidative stress and Ramadan observance; a possible influence of associated dieting

Introduction: The effects of Ramadan observance and any associated dietary restriction upon oxidative stress are not well known. The topic has thus been examined in a brief systematic review of available literature concerning non-athletic but otherwise healthy subjects, patients with selected clinical conditions, and in athletes. Methods: Ovid/Medline and Google searches were supplemented by a ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Nutricion hospitalaria

دوره 34 3  شماره 

صفحات  -

تاریخ انتشار 2017